Recovery of an integration shuttle vector from tandem repeats in Methanococcus maripaludis

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Recovery of an integration shuttle vector from tandem repeats in Methanococcus maripaludis.

Transformation of Methanococcus maripaludis by using an integration vector, pKAS102, is described. Selection and subsequent growth at high concentrations of puromycin caused pKAS102 to develop tandem repeats within the genome. As a result, total DNA isolated from the transformant could be used to recover the intact vector by direct transformation of competent Escherichia coli.

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We have used genetic methods in Methanococcus maripaludis to study nitrogen metabolism and its regulation. We present evidence for a "nitrogen regulon" in Methanococcus and Methanobacterium species containing genes of nitrogen metabolism that are regulated coordinately at the transcriptional level via a common repressor binding site sequence, or operator. The implied mechanism for regulation re...

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ژورنال

عنوان ژورنال: Applied and Environmental Microbiology

سال: 1991

ISSN: 0099-2240,1098-5336

DOI: 10.1128/aem.57.9.2762-2763.1991